Canada price comparison · Florida
Entresto from Canada vs. U.S. price (2026)
Last updated October 9, 2026 · Reviewed by the LowerScript editorial team · Español
Short answer. Entresto (sacubitril/valsartan) was listed at $264.50 for 60 tabs (49mg/51mg, Product of Canada) at Great North Pharmacy on October 9, 2026. We do not have an exact LowerScript price for this strength and pack near Tampa (ZIP 33602) yet; the table shows the closest match marked *. From October 22, 2026, U.S. Customs suspends the low-value “de minimis” shipping exemption, and Canadian mail-order pharmacies expect prescription shipments to Americans to stop or become much harder.
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Entresto: Canadian price vs. Tampa price
| Medicine | Canadian online pharmacy (listed price, source) | LowerScript near Tampa: brand-name | LowerScript near Tampa: generic |
|---|---|---|---|
| Entresto (sacubitril/valsartan) heart failure ✓ Medicare-negotiated price (2026) Compare your price at LowerScript | $264.50 for 60 tabs 49mg/51mg · 30-day supply · brand-name listing Product of Canada · Great North Pharmacy | $759.61* 26 mg · qty 60 · as of Oct 9 | $72.83* 26 mg · qty 60 · as of Oct 9 |
* Closest match: where we could not price the exact strength or pack size, we show the nearest strength or pack of the same medicine. Check your exact prescription with the price check.
Canadian price: Great North Pharmacy’s public product page, captured October 9, 2026. The page shows prices with a “$” and does not name the currency; we treat them as U.S. dollars (see the method note on the Florida Canada guide). Shipping is not included. LowerScript prices come from our price tool at ZIP 33602 (Tampa): the lowest price among nearby in-network pharmacies for the strength and quantity shown. Prices change, and strengths and packs can differ between countries, so compare the labels. This page compares listed prices; it is not a recommendation to buy from any seller and not medical advice.
What changes on October 22
The Associated Press reported on October 8, 2026 that the “de minimis” exemption for shipments valued under $800 is suspended starting October 22, 2026, and that medications mailed from outside the U.S. will then need additional data and a bond. The rule does not specifically target Canadian drugs, and this page takes no position on it. Source: Associated Press, via U.S. News, October 8, 2026.
Is there a generic?
Our data includes a generic: sacubitril/valsartan. We could price only a closest match for it, marked * in the table.
Medicare
Entresto is on the list of drugs with Medicare-negotiated prices that took effect January 1, 2026. In 2026, Part D out-of-pocket drug costs are capped at $2,100 a year. Open enrollment runs October 15 – December 7, 2026; compare plans at Medicare.gov. Sources: CMS 2027 landscape fact sheets (dates) and Nasdaq’s summary of 2026 Medicare changes (cap and drug list).
Frequently asked questions
How much is Entresto in Canada compared with Tampa?
Entresto (sacubitril/valsartan) was listed at $264.50 for 60 tabs (49mg/51mg, Product of Canada) at Great North Pharmacy on October 9, 2026. We do not have an exact LowerScript price for this strength and pack near Tampa (ZIP 33602) yet; the table shows the closest match marked *. Shipping is not included in the Canadian price and prices change, so check the current price of your own medicine and strength.
Will my Entresto order from Canada still arrive after October 22?
We can’t predict that. The Associated Press reports that Canadian pharmacies expect shipments to Americans to stop or become much harder once the federal rule takes effect on October 22. Compare your price at LowerScript before your next refill.
Is LowerScript insurance?
No. LowerScript is a free prescription discount program, not insurance. At a participating pharmacy you pay the discounted cash price instead of using insurance for that fill.
Can I use LowerScript if I have Medicare?
The LowerScript card can’t be combined with Medicare on the same purchase, but you can choose, fill by fill, to pay the discounted cash price instead of using your plan. A fill paid with the card does not count toward your plan’s out-of-pocket cap, so weigh that if you are close to it. See our guide: Can you use a discount card with Medicare?
This guide is general information, not medical, legal or financial advice. LowerScript is a prescription discount program, not insurance.